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The
electrophysiological basis of the EKG depends on the spread of electrical
stimuli through the atria and ventricles.
During rest, myocardial fibers are polarized, i.e., a difference in
potential exists between the inside and outside of the cell (known as
membrane potential, -90 mV). This is due to the selective ionic permeability
of the cell membrane, resulting in the creation of a stable positive electric
charge on the outer surface. Inside
the cell, potassium ions predominate, outside it sodium ions. When a myocardial fiber is stimulated, an
immediate change in the membrane permeability, and consequent sodium ions
transfer into cells give rise to action potential. The result is an abrupt conversion of the negative membrane
potential into a positive one (+30 mV), which is called depolarization. During the subsequent repolarization of
the myocardial fibers, potassium ions pass out of the cell and the action
potential is annihilated. The EKG
records the electrical activity of the atrial and ventricular muscles, not
just the electrical activity of a single myofibril. Since cardiac depolarization and repolarization normally occur
in a synchronized fashion, the EKG is able to record these electric currents
as specific waves: P wave due to atrial depolarization; QRS complex due to
ventricular depolarization; and ST segment, T wave and U wave due to
ventricular repolarization or recovery.
Alcohol Causes: Atrial fibrillation, Prolonged Q-T interval, Inverted
T waves, Heart block, Ventricular arrhythmias, Holiday heart syndrome, and
Sudden death.
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Beckemeier,
M.E.; Bora, P.S. Fatty Acid Ethyl Esters: Potentially Toxic Products of
Myocardial Ethanol Metabolism. J Mol Cell Card, 30:2487-2497, 1998.
|
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Chadwick, D.J.;
Goode, J.A. (Eds.) Alcohol and Cardiovascular Diseases: Novartis
Foundation Symposium 216. New York, NY: John Wiley and
Sons, 1998. 272p
|
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Kupari, M.;
Koskinen, P. Alcohol, Cardiac Arrhythmias and Sudden Death. In: D.J.
Chadwick and J.A. Goode, Eds., Alcohol and Cardiovascular Diseases: Novartis
Foundation Symposium 216, New York, NY: John Wiley and Sons, 1998, pp. 68-85.
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Mukamal, K.J.;
Muller, J.E.; Maclure, M.; Sherwood, J.B.; Mittleman, M.A. Lack
of Effect of Recent Alcohol Consumption on the Course of Acute Myocardial
Infarction. Am Heart J,138:926-933, 1999.
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Puddey, I.B.;
Rakic, V.; Dimmitt, S.B.; Beilin, L.J. Influence of Pattern of Drinking on
Cardiovascular Disease and
Cardiovascular Risk Factors: A Review. Addiction, 94:649-663,
1999.
|
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Rosenqvist, M. Alcohol
and Cardiac Arrhythmias. Alcoholism: C Exp Res, 22(7 suppl.):318S-322S,
1998.
|
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Rossinen, J.;
Sinisalo, J.; Partanen, J.; Nieminen, M.S.; Viitasalo, M. Effects
of Acute Alcohol Infusion on Duration and Dispersion of QT Interval in Male
Patients with Coronary Artery Disease and in Healthy Controls. Clinical
Cardiology, 22:591-594, 1999.
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