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Picture
Modified from National Geographic, 181:14, 1992
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Cardiomyopathy,
a degenerative disease of the heart in the absence of coronary artery
disease, is a well-established complication of chronic alcohol abuse. Most cases are probably asymptomatic, but
in some patients this leads to arrhythmias, cardiomegaly and congestive heart
failure, characterized by dyspnea and peripheral edema. Treating alcoholic cardiomyopathy involves
the use of supportive measures and principally must include abstinence from
alcohol. Alcoholic cardiomyopathy
could be due to the accumulation of fatty acids ethyl esters (FAEE) --
neutral molecules that are present in the heart and other organs that lack
oxidative ethanol metabolism – in the mitochondria. However, heart myocardial respiratory chain complex are
functionally not affected in heavy drinkers without cardiomyopathy. Alcohol also alters protein metabolism.
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Beckemeier,
M.E.; Bora, P.S. Fatty Acid Ethyl Esters: Potentially Toxic Products of
Myocardial Ethanol Metabolism. Journal of Molecular and Cellular
Cardiology, 30:2487-2497, 1998.
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Constant, J. Alcoholic
Cardiomyopathies: Genuine and Pseudo. Cardiology, 91:92-95, 1999.
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Gavazzi, A.;
Maria, R.D.; Paronili, M.; Porcu, M. Italian Multicenter Cardiomyopathy Study
Group (SPIC) Alcohol Abuse and Dilated Cardiomyopathy in Men. American
Journal of Cardiology, 85:1114-1118, 2000.
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Lazarevic, A.M.;
Nakatani, S.; Neskovic, A.N.; Marinkovic, J.; Yasumura, Y.; Stojicic, D.;
Miyatake, K.; Bojic, M.; Popovic, A.D. Early Changes in Left Ventricular
Function in Chronic Asymptomatic Alcohlics: Relation to the Duration of Heavy
Drinking. Journal of the American College of Cardiology, 35:1599-1606,
2000.
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McKenna, C.J.;
Codd, M.B.; McCann, H.A.; Sugrue, D.D. Alcohol Consumption and Idiopathic
Dilated Cardiomyopathy: A Case Control Study. American
Heart Journal, 135:833-837, 1998.
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Miro, O.;
Robert, J.; Casademont, J.; Alonso, J.R.; Nicolas, J.M.; Fernandez-Sola, J.;
Urbano-Marquez, A.; Hoek, J.B.; Cardellach, F. Heart Mitochondrial
Respiratory Chain Complexes are Functionally Unaffected in Heavy Ethanol
Drinkers Without Cardiomyopathy. Alcoholism: Clinical and Experimental
Research, 24:859-864, 2000.
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Preedy, V.R.;
Reilly, M.E.; Patel, V.B.; Richardson, P.J.; Peters, T.J. Protein
Metabolism in Alcoholism: Effects on Specific Tissues and the Whole Body.
Nutrition, 15:604-608, 1999.
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Rubin E and
Urbano-Marquez A: Clinical Effects
of Alcohol on the Cardiovascular System, In: Alcohol and the
Cardiovascular System, Zakhari S and Wassef M (eds), NIH Publication No.
96-4133, 1996, pp127-136.
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Stollberger, C.;
Finsterer, J. Reversal of Dilated to Hypertrophic Cardiomyopathy After
Alcohol Abstinence. Clinical Cardiology, 21:365-367, 1998.
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Waldenstrom, A. Alcohol
and Congestive Heart Failure. Alcoholism: Clinical and Experimental
Research, 22(7 suppl.):315S-317S, 1998.
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